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Volume 13, Issue 1 (Spring 2011)
Advances in Cognitive Sciences 2011, 13(1): 81-92 |
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Piri M, Nasehi M, Pournaghshband M, Shahin M, Zarrindast M R. Dopamine D1 and NMDA Receptors Interaction in the Dorsal Hippocampus of Rats in the Elevated Plus Maze Test of Anxiety. Advances in Cognitive Sciences 2011; 13 (1) :81-92
URL: http://icssjournal.ir/article-1-321-en.html
URL: http://icssjournal.ir/article-1-321-en.html
Morteza Piri *1 
, Mohamad Nasehi2 , Mahnaz Pournaghshband3 , Maryam-sadat Shahin4 , Mohammad Reza Zarrindast5
, Mohamad Nasehi2 , Mahnaz Pournaghshband3 , Maryam-sadat Shahin4 , Mohammad Reza Zarrindast5
1- Islamic Azad University, Ardabil Branch, Ardabil, Iran.
2- Islamic Azad University, Garmsar Branch, Garmsar, Iran.
3- Islamic Azad University, Pharmaceutical Science Branch (IAUPS), Tehran, Iran.
4- Young Researchers Club, Islamic Azad University, Shahr-e-Rey Branch, Rey, Iran.
5- Tehran University of Medical Sciences, Tehran, Iran.
2- Islamic Azad University, Garmsar Branch, Garmsar, Iran.
3- Islamic Azad University, Pharmaceutical Science Branch (IAUPS), Tehran, Iran.
4- Young Researchers Club, Islamic Azad University, Shahr-e-Rey Branch, Rey, Iran.
5- Tehran University of Medical Sciences, Tehran, Iran.
Abstract: (2811 Views)
Objective: In this study the effects of dopaminergic D1 receptor of dorsal hippocampus on anxiety-like behavior induced by stimulation or inhibition of NMDA receptors were investigated in male Wistar rats.
Method: The elevated plus maze was used in the present study, which is an accepted model to examine anxiety-like behaviors in mice and rats.
Results: The results indicate that intra-CA1injection of MK801 (2 μg/rat) induce anxiolytic effects. Intra-CA1 injection of SCH23390 (0.25, 0.5 and 1 μg/rat) by itself has no effect on anxiety-like behaviors, but administration of same doses of SCH23390 before MK801 (1 μg/rat, intra-CA1) potentiate anxiolytic effects of MK801. On the other hand, intra-CA1 injection of NMDA (0.3 and 0.6 μg/rat) or SKF 38393 (3 and 6 μg/rat) by itself induces anxiogenic effects. Injection of different doses of SKF38393 before NMDA potentiated anxiogenic effects of NMDA.
Conclusion: These results show that both NMDA receptor and dopaminergic D1 receptor not only play a part in the modulation of anxiety in the dorsal hippocampus of rats but also have demonstrated a complex interaction as well.
Method: The elevated plus maze was used in the present study, which is an accepted model to examine anxiety-like behaviors in mice and rats.
Results: The results indicate that intra-CA1injection of MK801 (2 μg/rat) induce anxiolytic effects. Intra-CA1 injection of SCH23390 (0.25, 0.5 and 1 μg/rat) by itself has no effect on anxiety-like behaviors, but administration of same doses of SCH23390 before MK801 (1 μg/rat, intra-CA1) potentiate anxiolytic effects of MK801. On the other hand, intra-CA1 injection of NMDA (0.3 and 0.6 μg/rat) or SKF 38393 (3 and 6 μg/rat) by itself induces anxiogenic effects. Injection of different doses of SKF38393 before NMDA potentiated anxiogenic effects of NMDA.
Conclusion: These results show that both NMDA receptor and dopaminergic D1 receptor not only play a part in the modulation of anxiety in the dorsal hippocampus of rats but also have demonstrated a complex interaction as well.
Type of Study: Research |
Subject:
Special
Received: 2010/11/22 | Accepted: 2011/01/21 | Published: 2011/03/21
Received: 2010/11/22 | Accepted: 2011/01/21 | Published: 2011/03/21
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