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Volume 9, Issue 2 (Summer 2007)
Advances in Cognitive Sciences 2007, 9(2): 1-11 |
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Zat Ali H, Rezayof A, Zarindast M, Haeri Rouhani A, Razavi Movahed S. The Effect of Nicotinic Receptors of Dorsal Hippocampus on Psychological Dependence in Wistar Rats. , Advances in Cognitive Sciences. 2007; 9 (2) :1-11
URL: http://icssjournal.ir/article-1-341-en.html
URL: http://icssjournal.ir/article-1-341-en.html
Hengameh Zat Ali * 
, Amaneh Rezayof , Mohammadreza Zarindast , Ali Haeri Rouhani , Samira Razavi Movahed
, Amaneh Rezayof , Mohammadreza Zarindast , Ali Haeri Rouhani , Samira Razavi Movahed
Abstract: (3872 Views)
Objective: In this study, the effects of bilateral injections of nicotinic cholinergic agents into the hippocampal CA1region of Wistar rats on morphine-induced conditioned place preference (CPP) was studied.
Method: All animals were canulated in the CA1 area of dorsal hippocampus by stereotaxic instrument. Each animal was allowed to recover 1-week before CPP induction. We used a 5-day schedule for CPP with three distinct phases: first, the preconditioning phase, second, the conditioning phase and finally, the testing or the expression phase.
Results: Subcutaneous administration of different doses of morphine sulphate (0.5-6mg/kg) produced a dose-dependent CPP. Using a 3-day schedule of conditioning, it was found that intra-CA1 administration of nicotine (0.5, 0.75, and 1mg/rat) with an ineffective dose of morphine (0.5mg/kg) elicited a significant CPP. Bilateral injections of different doses of the nicotinic receptor antagonist, mecamylamine (2, 4, and 8mg/rat) into the CA1 regions significantly inhibited the morphine (6mg/kg)-induced CPP. Moreover mecamylamine (8mg/rat, intra-CA1) decreased the effect of nicotine-induced potentiation of the morphine response.
Conclusion: Intra-CA1 injections of nicotine or mecamylamine alone did not induce a significant place preference or place aversion. It may be concluded that the nicotinic receptors of the hippocampal CA1 regions play an important role in morphine reward.
Method: All animals were canulated in the CA1 area of dorsal hippocampus by stereotaxic instrument. Each animal was allowed to recover 1-week before CPP induction. We used a 5-day schedule for CPP with three distinct phases: first, the preconditioning phase, second, the conditioning phase and finally, the testing or the expression phase.
Results: Subcutaneous administration of different doses of morphine sulphate (0.5-6mg/kg) produced a dose-dependent CPP. Using a 3-day schedule of conditioning, it was found that intra-CA1 administration of nicotine (0.5, 0.75, and 1mg/rat) with an ineffective dose of morphine (0.5mg/kg) elicited a significant CPP. Bilateral injections of different doses of the nicotinic receptor antagonist, mecamylamine (2, 4, and 8mg/rat) into the CA1 regions significantly inhibited the morphine (6mg/kg)-induced CPP. Moreover mecamylamine (8mg/rat, intra-CA1) decreased the effect of nicotine-induced potentiation of the morphine response.
Conclusion: Intra-CA1 injections of nicotine or mecamylamine alone did not induce a significant place preference or place aversion. It may be concluded that the nicotinic receptors of the hippocampal CA1 regions play an important role in morphine reward.
Keywords: Morphine, Nicotinic Receptor Agonist and Antagonist, Conditioned Place Preference, Dorsal Hippocampus, Rat
Type of Study: Research |
Subject:
Special
Received: 2007/03/14 | Accepted: 2007/04/21 | Published: 2007/06/22
Received: 2007/03/14 | Accepted: 2007/04/21 | Published: 2007/06/22
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