Tue, Apr 16, 2024
| فارسی
Volume 9, Issue 2 (Summer 2007)
Advances in Cognitive Sciences 2007, 9(2): 1-11 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Zat Ali H, Rezayof A, Zarindast M, Haeri Rouhani A, Razavi Movahed S. The Effect of Nicotinic Receptors of Dorsal Hippocampus on Psychological Dependence in Wistar Rats. Advances in Cognitive Sciences 2007; 9 (2) :1-11
URL: http://icssjournal.ir/article-1-341-en.html
URL: http://icssjournal.ir/article-1-341-en.html
Hengameh Zat Ali * 
, Amaneh Rezayof , Mohammadreza Zarindast , Ali Haeri Rouhani , Samira Razavi Movahed
, Amaneh Rezayof , Mohammadreza Zarindast , Ali Haeri Rouhani , Samira Razavi Movahed
Abstract: (2353 Views)
Objective: In this study, the effects of bilateral injections of nicotinic cholinergic agents into the hippocampal CA1region of Wistar rats on morphine-induced conditioned place preference (CPP) was studied.
Method: All animals were canulated in the CA1 area of dorsal hippocampus by stereotaxic instrument. Each animal was allowed to recover 1-week before CPP induction. We used a 5-day schedule for CPP with three distinct phases: first, the preconditioning phase, second, the conditioning phase and finally, the testing or the expression phase.
Results: Subcutaneous administration of different doses of morphine sulphate (0.5-6mg/kg) produced a dose-dependent CPP. Using a 3-day schedule of conditioning, it was found that intra-CA1 administration of nicotine (0.5, 0.75, and 1mg/rat) with an ineffective dose of morphine (0.5mg/kg) elicited a significant CPP. Bilateral injections of different doses of the nicotinic receptor antagonist, mecamylamine (2, 4, and 8mg/rat) into the CA1 regions significantly inhibited the morphine (6mg/kg)-induced CPP. Moreover mecamylamine (8mg/rat, intra-CA1) decreased the effect of nicotine-induced potentiation of the morphine response.
Conclusion: Intra-CA1 injections of nicotine or mecamylamine alone did not induce a significant place preference or place aversion. It may be concluded that the nicotinic receptors of the hippocampal CA1 regions play an important role in morphine reward.
Method: All animals were canulated in the CA1 area of dorsal hippocampus by stereotaxic instrument. Each animal was allowed to recover 1-week before CPP induction. We used a 5-day schedule for CPP with three distinct phases: first, the preconditioning phase, second, the conditioning phase and finally, the testing or the expression phase.
Results: Subcutaneous administration of different doses of morphine sulphate (0.5-6mg/kg) produced a dose-dependent CPP. Using a 3-day schedule of conditioning, it was found that intra-CA1 administration of nicotine (0.5, 0.75, and 1mg/rat) with an ineffective dose of morphine (0.5mg/kg) elicited a significant CPP. Bilateral injections of different doses of the nicotinic receptor antagonist, mecamylamine (2, 4, and 8mg/rat) into the CA1 regions significantly inhibited the morphine (6mg/kg)-induced CPP. Moreover mecamylamine (8mg/rat, intra-CA1) decreased the effect of nicotine-induced potentiation of the morphine response.
Conclusion: Intra-CA1 injections of nicotine or mecamylamine alone did not induce a significant place preference or place aversion. It may be concluded that the nicotinic receptors of the hippocampal CA1 regions play an important role in morphine reward.
Keywords: Morphine, Nicotinic Receptor Agonist and Antagonist, Conditioned Place Preference, Dorsal Hippocampus, Rat
Type of Study: Research |
Subject:
Special
Received: 2007/03/14 | Accepted: 2007/04/21 | Published: 2007/06/22
Received: 2007/03/14 | Accepted: 2007/04/21 | Published: 2007/06/22
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
