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Volume 11, Issue 2 (Summer 2009)
Advances in Cognitive Sciences 2009, 11(2): 27-37 |
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Piri M, Zarrindast M R, Oryan S. Effects of cannabinoidergic system of CA1 area of dorsal hippocampus on the memory of nicotine sensitized rats. Advances in Cognitive Sciences 2009; 11 (2) :27-37
URL: http://icssjournal.ir/article-1-36-en.html
URL: http://icssjournal.ir/article-1-36-en.html
1- Islamic Azad University، Ardabil, Iran
2- Tehran Medical Science University, Tehran, Iran
3- Tarbiat Moalem University, Tehran, Iran.
2- Tehran Medical Science University, Tehran, Iran
3- Tarbiat Moalem University, Tehran, Iran.
Abstract: (2901 Views)
Objective: In the present study, the effects of double route administration of canabinoid agonists and antagonists of dorsal hippocampus (CA1) was investigated on the memory of nicotine-sensitized rats.
Method: Passive avoidance task with Step-through model was used to evaluate memory in wistar rats, which was assessed 24 hours after training.
Results: Intracranial administration of WIN55, 212-2 (0.3 , 0.6 μg/rat) and CB1 receptor antagonist, AM251 (30 , 60 ng/rat, intra–CA1)on training day, led to memory impairment in rats. Intracranial administration of AM251 two minutes before the intracranial injection of WIN55, 212-2 (0.3 μg/rat) could not alter memory impairment induced by WIN55, 212-2(0.3 μg/rat). The memory destructive effect of WIN55, 212-2(0.3 μg/rat) and AM251 (60 ng/rat) subsequent to five day administration of different doses of nicotine (0.2, 0.4 and 0.6 mg/ kg) ten days before the injection of WIM55, 212-2 or AM251, disappeared completely.
Conclusion: Dorsal Hippocampus has a crucial role in cannabinoid induced amnesia. Five day administration of nicotine could possibly lead to sensitizataion of nicotine receptors and therefore effect the amnesia induced by canabinoid drugs.
Method: Passive avoidance task with Step-through model was used to evaluate memory in wistar rats, which was assessed 24 hours after training.
Results: Intracranial administration of WIN55, 212-2 (0.3 , 0.6 μg/rat) and CB1 receptor antagonist, AM251 (30 , 60 ng/rat, intra–CA1)on training day, led to memory impairment in rats. Intracranial administration of AM251 two minutes before the intracranial injection of WIN55, 212-2 (0.3 μg/rat) could not alter memory impairment induced by WIN55, 212-2(0.3 μg/rat). The memory destructive effect of WIN55, 212-2(0.3 μg/rat) and AM251 (60 ng/rat) subsequent to five day administration of different doses of nicotine (0.2, 0.4 and 0.6 mg/ kg) ten days before the injection of WIM55, 212-2 or AM251, disappeared completely.
Conclusion: Dorsal Hippocampus has a crucial role in cannabinoid induced amnesia. Five day administration of nicotine could possibly lead to sensitizataion of nicotine receptors and therefore effect the amnesia induced by canabinoid drugs.
Type of Study: Research |
Subject:
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Received: 2009/02/19 | Accepted: 2009/04/21 | Published: 2009/06/22
Received: 2009/02/19 | Accepted: 2009/04/21 | Published: 2009/06/22
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