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Volume 8, Issue 1 (Spring 2006)
Advances in Cognitive Sciences 2006, 8(1): 9-16 |
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Satari Naeini M, Oryan S, Babapour V, Alibalaie M. The Interaction of Morphine, Glucose and ATP Sensitive Potassium Channels on the Consolidation of Morphine Induced Place Preference. Advances in Cognitive Sciences 2006; 8 (1) :9-16
URL: http://icssjournal.ir/article-1-324-en.html
URL: http://icssjournal.ir/article-1-324-en.html
1- Department of Science and Research, Islamic Azad University, Tehran, Iran.
Abstract: (2413 Views)
Objective: In the present study interaction of glucose and ATP sensitive potassium channels on the consolidation of morphine induced place preference in male mice has been investigated.
Methods: Conditioned place preference method was used to assess morphine reward and effects of glucose ,glibenclamide and diazoxide on it.
Results: Intraperitoneal administration of different doses of morphine sulphate (0.5-7.5 mg/kg IP) produced a dose-dependent conditioned place preference (cpp). However, the isolated administration of different doses of glibenclamide (3,6 AND12mg/kg IP), diazoxide (15, 30 and 60mg/kg IP) and glucose (100, 200, 500, 2000 mg/kg) did not produce such an effect. The injection of glucose (2000 mg/kg IP) and glibenclamide (6 mg/kg IP) produced significant morphine (0.5 mg/kg IP) induced cpp. Also, the response of glibenclamide (6mg/kg IP) was attenuated by diazoxide (60 mg /kg IP). However, this dose of diazoxide alone had no effect on morphine (0.5 mg/kg IP) induced cpp .Injection of different doses of diazoxide (15, 30 and 60mg/kg IP), glibenclamide (3, 6 and 12mg/kg IP) and morphine (0.5-7.5 mg/kg) did not effect blood glucose level.
Conclusion: It is concluded that glucose may be involved in morphine induced conditioned place preference through KATP channels.
Methods: Conditioned place preference method was used to assess morphine reward and effects of glucose ,glibenclamide and diazoxide on it.
Results: Intraperitoneal administration of different doses of morphine sulphate (0.5-7.5 mg/kg IP) produced a dose-dependent conditioned place preference (cpp). However, the isolated administration of different doses of glibenclamide (3,6 AND12mg/kg IP), diazoxide (15, 30 and 60mg/kg IP) and glucose (100, 200, 500, 2000 mg/kg) did not produce such an effect. The injection of glucose (2000 mg/kg IP) and glibenclamide (6 mg/kg IP) produced significant morphine (0.5 mg/kg IP) induced cpp. Also, the response of glibenclamide (6mg/kg IP) was attenuated by diazoxide (60 mg /kg IP). However, this dose of diazoxide alone had no effect on morphine (0.5 mg/kg IP) induced cpp .Injection of different doses of diazoxide (15, 30 and 60mg/kg IP), glibenclamide (3, 6 and 12mg/kg IP) and morphine (0.5-7.5 mg/kg) did not effect blood glucose level.
Conclusion: It is concluded that glucose may be involved in morphine induced conditioned place preference through KATP channels.
Type of Study: Research |
Subject:
Special
Received: 2005/09/24 | Accepted: 2005/12/19 | Published: 2006/03/21
Received: 2005/09/24 | Accepted: 2005/12/19 | Published: 2006/03/21
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