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Volume 7, Issue 3 (Autumn 2005)
Advances in Cognitive Sciences 2005, 7(3): 16-24 |
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Zarindast M, Fazli Tabaei S, Ahmadi S, Yahyavi H. Effect of Lithium on Morphine Induced State-Dependent Memory in A Passive Avoidance Task in Nmri Mice. Advances in Cognitive Sciences 2005; 7 (3) :16-24
URL: http://icssjournal.ir/article-1-147-en.html
URL: http://icssjournal.ir/article-1-147-en.html
Abstract: (2654 Views)
Objective: In the present study, the effects of lithium chloride (LiCl) on morphine induced state-dependent memory were examined in NMRI mice in a passive avoidance task.
Method: In this experimental study one-trial step-down paradigm was used for the assessment of memory in adult male NMRI mice.
Results: Administration of morphine (5 mg/kg) subcutaneously (S.C.) 30 min before training or testing induced impairment of memory formation. Injection of the same dose of the drug 30 min before testing restored retrieval of memory impaired under pre-training morphine effect. intraperitoneal (I.P.) injection of lithium, 60 min before training or prior to testing also impaired memory retrieval. Impaired memory was restored in animals that had received LiCl (80 and 160 mg/kg) as pre-test injection in cases of pre-training administration of morphine. Pre-training administration of lower doses of lithium (20 mg/kg) impaired memory storage in passive avoidance test. LiCl-induced impairment of memory was restored by pre-test administration of morphine. In animals receiving pre-training morphine, combined pre-test morphine and LiCl administration increased the restoration of memory impaired by the opioid.
Conclusion: Considering the results, an interaction between state dependency of morphine and lithium might be present.
Method: In this experimental study one-trial step-down paradigm was used for the assessment of memory in adult male NMRI mice.
Results: Administration of morphine (5 mg/kg) subcutaneously (S.C.) 30 min before training or testing induced impairment of memory formation. Injection of the same dose of the drug 30 min before testing restored retrieval of memory impaired under pre-training morphine effect. intraperitoneal (I.P.) injection of lithium, 60 min before training or prior to testing also impaired memory retrieval. Impaired memory was restored in animals that had received LiCl (80 and 160 mg/kg) as pre-test injection in cases of pre-training administration of morphine. Pre-training administration of lower doses of lithium (20 mg/kg) impaired memory storage in passive avoidance test. LiCl-induced impairment of memory was restored by pre-test administration of morphine. In animals receiving pre-training morphine, combined pre-test morphine and LiCl administration increased the restoration of memory impaired by the opioid.
Conclusion: Considering the results, an interaction between state dependency of morphine and lithium might be present.
Keywords: Lithium, Morphine, Step-Down Paradigm, Passive Avoidance, Memory, State-Dependent Learning
Type of Study: Research |
Subject:
Special
Received: 2005/04/23 | Accepted: 2005/07/23 | Published: 2005/09/23
Received: 2005/04/23 | Accepted: 2005/07/23 | Published: 2005/09/23
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