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Volume 7, Issue 1 (Spring 2005)
Advances in Cognitive Sciences 2005, 7(1): 18-27 |
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Bonanej M, Rezayof A, Haeri Rouhani A, Zarindast M, Khalilzadeh A, Fazli Tabaei S. The Effect of Intraventricular Injection of Dopaminergic Drugs on Morphine Dependent Memory, Based on Passive Avoidance Task. Advances in Cognitive Sciences 2005; 7 (1) :18-27
URL: http://icssjournal.ir/article-1-114-en.html
URL: http://icssjournal.ir/article-1-114-en.html
Mayam Bonanej 
, Amaneh Rezayof , Ali Haeri Rouhani , Mohammadreza Zarindast * 1, Azita Khalilzadeh , Soheila Fazli Tabaei
, Amaneh Rezayof , Ali Haeri Rouhani , Mohammadreza Zarindast * 1, Azita Khalilzadeh , Soheila Fazli Tabaei
Abstract: (2457 Views)
Objective: In this experiment, the effects of dopaminergic drugs on morphine state dependent memory were examined in mice, based on the passive avoidance task.
Method: In this experimental research, morphine and saline were administered subcutaneously, and dopaminergic drugs were administered cerebroventricularly (into the brain). Then (using Passive Avoidance Apparatus) step-down latency was measured, which shows the memory of the animal.
Results: Pre- training subcutaneous administration of morphin (5mg/kg) led to the impairment of retrieval memory but the administration of the same dose on the test day led to state-dependent memory (learning). The pre-test intracerebroventricular (ICV) administration of the D1 agonist (SKF 38393), D2 agonist (quinpirole) and D2 blocker (sulpiride) not only mimiced the effect of pre-test morphine treatment, but also increased the function of opioids. Furthermore, the pre-test ICV administration of D1 antagonist (SCH 23390) prevented the restoration of memory by morphine.
Conclusion: Effects of mrphine on some memory pathways seems to be induced through dopamine receptors.
Method: In this experimental research, morphine and saline were administered subcutaneously, and dopaminergic drugs were administered cerebroventricularly (into the brain). Then (using Passive Avoidance Apparatus) step-down latency was measured, which shows the memory of the animal.
Results: Pre- training subcutaneous administration of morphin (5mg/kg) led to the impairment of retrieval memory but the administration of the same dose on the test day led to state-dependent memory (learning). The pre-test intracerebroventricular (ICV) administration of the D1 agonist (SKF 38393), D2 agonist (quinpirole) and D2 blocker (sulpiride) not only mimiced the effect of pre-test morphine treatment, but also increased the function of opioids. Furthermore, the pre-test ICV administration of D1 antagonist (SCH 23390) prevented the restoration of memory by morphine.
Conclusion: Effects of mrphine on some memory pathways seems to be induced through dopamine receptors.
Type of Study: Research |
Subject:
Special
Received: 2004/11/11 | Accepted: 2005/01/10 | Published: 2005/03/21
Received: 2004/11/11 | Accepted: 2005/01/10 | Published: 2005/03/21
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