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Volume 22, Issue 1 (Spring 2020)
Advances in Cognitive Sciences 2020, 22(1): 61-69 |
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Shayan Nooshabadi A, Dowlati M A, Zar A. The effect of brain-derived neurotrophic factor single nucleotide polymorphism on memory of university students. Advances in Cognitive Sciences 2020; 22 (1) :61-69
URL: http://icssjournal.ir/article-1-946-en.html
URL: http://icssjournal.ir/article-1-946-en.html
1- Assistant of Motor Behavior, Department of Sport Sciences, Faculty of Literature and Humanities, Jahrom University, Jahrom, Iran
2- Assistant Professor of Medical Genetics, Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences and Health Services, Kashan, Iran
3- Associate Professor of Exercise Physiology, Department of Sport Science, Faculty of Literature and Humanities, Persian Gulf University, Boushehr, Iran
2- Assistant Professor of Medical Genetics, Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences and Health Services, Kashan, Iran
3- Associate Professor of Exercise Physiology, Department of Sport Science, Faculty of Literature and Humanities, Persian Gulf University, Boushehr, Iran
Abstract: (2279 Views)
Introduction: Brain-derived neurotrophic factor (BDNF) is one of the most abundant neurotrophic factors in the adult brain associated with synaptic plasticity, learning, memory and cognitive processes reinforcement. The advent of val66met polymorphism in codon 66 of the BDNF gene, disrupted this protein’s secretion. The purpose of the study is to investigate of the effect of brain-derived neurotrophic factor single nucleotide polymorphism on memory score and memory quotient.
Methods: One hundred native male students from Kashan University, Iran (mean age 21.60±2.20) were randomly selected. After extraction of Genomic DNA, the polymerase chain reaction (PCR) was implemented by forwarding primer 5-ACTCTGGAGAGCGTGAAT-3 and reverse primer 5-ATACTGTCACACACGCTG-3, analyzing PCR by 1.5 percent Electrophoresis Gel. In the end, sequencing by ABI PRISM 7000 Sequencing Analyzer, some participants were identified without val66met polymorphism while the others were affected by the polymorphism (met-carrier). We used Wechsler memory tested assess memory score and memory quotient of participants. Also, we used from SPSS software for data analysis and test the research hypothesis.
Results: Results revealed that people without the polymorphism were significantly better than met-carriers in memory score and memory quotient (P<0.001). The study of Wechsler's subscales showed that this superiority was more affected by logical memory subscales and associative learning.
Conclusion: In general, the results represent the effect of val66met polymorphism on memory and memory quotient, so that the existence of this polymorphism in some people may weaken their ability in compression with people without polymorphism, due to disruption of BDNF secretion.
Methods: One hundred native male students from Kashan University, Iran (mean age 21.60±2.20) were randomly selected. After extraction of Genomic DNA, the polymerase chain reaction (PCR) was implemented by forwarding primer 5-ACTCTGGAGAGCGTGAAT-3 and reverse primer 5-ATACTGTCACACACGCTG-3, analyzing PCR by 1.5 percent Electrophoresis Gel. In the end, sequencing by ABI PRISM 7000 Sequencing Analyzer, some participants were identified without val66met polymorphism while the others were affected by the polymorphism (met-carrier). We used Wechsler memory tested assess memory score and memory quotient of participants. Also, we used from SPSS software for data analysis and test the research hypothesis.
Results: Results revealed that people without the polymorphism were significantly better than met-carriers in memory score and memory quotient (P<0.001). The study of Wechsler's subscales showed that this superiority was more affected by logical memory subscales and associative learning.
Conclusion: In general, the results represent the effect of val66met polymorphism on memory and memory quotient, so that the existence of this polymorphism in some people may weaken their ability in compression with people without polymorphism, due to disruption of BDNF secretion.
Type of Study: Research |
Received: 2019/05/20 | Accepted: 2019/10/14 | Published: 2020/06/10
Received: 2019/05/20 | Accepted: 2019/10/14 | Published: 2020/06/10
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