Introduction: Cognitive impairments, especially memory problems, are frequent in patients with Multiple Sclerosis (MS) and can reduce the quality of their life. The purpose of this study was to evaluate the effectiveness of computerized cognitive rehabilitation on the everyday memory of patients with MS. Methods: Forty-six patients aged 20-40 years with MS were randomly divided into two groups. Patients in the experimental group received 12 sessions using memory rehabilitation software, and the patients in waiting-list control group did not receive any interventions at that time, and their training was postponed to after the research. The data were collected using every memory inventory before, immediately after, and one month after the training sessions. Results: The results of repeated measures ANOVA showed that there is a meaningful difference between the mean scores of everyday memory in the two groups in the post-test. Also the no-meaningful difference between the post-test and follow-up scores in the experimental group indicates that computerized cognitive rehabilitation has significant effect on everyday memory performance of multiple sclerosis patients. Conclusions: Therefore, it can be concluded that cognitive rehabilitation has a significant effect on the improvement of the memory function of MS patients and can be used as an effective and useful method for improving the memory performance of them.