Volume 8, Issue 4 (Winter 2007)                   Advances in Cognitive Sciences 2007, 8(4): 11-21 | Back to browse issues page

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Heydari Darvishani A, Zarindast M, Rezayof A, Fathi Azarbayejani F E, Hajizadeh A. The Role of Gabaa Receptors in Morphine-Induced Locomotor Sensitization in Mice. Advances in Cognitive Sciences. 2007; 8 (4) :11-21
URL: http://icssjournal.ir/article-1-237-en.html
1- Department of Biology, Faculty of Basic Sciences, Urmia University, Urmia, Iran.
Abstract:   (1870 Views)
Objective: This study was aimed to assess the effects of a GABAA receptor agonist (muscimol) and an antagonist (bicuculline) on morphine-induced locomtor sensitization in male mice.
Method: 400 mice were cannulated by stereotaxy and made ready for injection. The program was performed in nine days and three stages. First, sensitization with medication was done in three days. Then for five deys mice did not receive any drugs, and finaly test was executed. Locomotor activity of the animals was registered for a period of 20 minutes after words. The locomtor behavioral response of a morphine challenge dose (5 mg/kg, s.c.) given on day nine was enhanced in mice pretreated with morphine (7.5, 15 and 30 mg/kg/day). Data were analysed by analysis of variance and Tukey's post hoc.
Results: subcutaneous injection of morphine (10, 20, 30, and 40, mg/kg) significantly increased the locomotor activity of the animals in a dose-dependent manner. Increase of locomotor activity in the mice with morphine pre-treatment (7.5, 15, and, 30 mg/kg) was a marker of sensitization. hree days administration of muscimol (0.025, 0.05,0.1, and 0.2 
mg/mouse/day) significantly decreased morphine-induced motor stimulation (5mg/kg) both in the presence or absence of morphine. On the other hand 3-days pre-treatment with bicuculline (0.25, 0.5, and 1 mg/mouse/day) with or without the prescence of morphine decreased the response of injection of muscimol (0.1 mg/mouse/day) to induction of locomotor activity by morphine (S mg/kg). Co-administration of bicuculline (0.1, 0.2, and 0.5 mg/mouse) and muscimol (0.1 mg/mouse) significantly decreased the morphine- induced locomotor activity in the animals pre-treated with saline or morphine (15 mg/kg).
Conclusion: The results indicate that GABAA receptors may be involved in development and expression of morphine –induced sensitization.
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Type of Study: Research | Subject: Special
Received: 2006/08/25 | Accepted: 2006/10/23 | Published: 2006/12/22

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