Volume 8, Issue 3 (Autumn 2006)                   Advances in Cognitive Sciences 2006, 8(3): 33-42 | Back to browse issues page

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Shaabani A, Eftekhar M, Danesh Amouz B, Khaniha H, Hakim Shoushtari M, Ghaleh Band M et al . Degree of Recurrence of Type I Bipolar Disorder: A 17 Month Follow-Up of Patients With First-Episode Mania. Advances in Cognitive Sciences. 2006; 8 (3) :33-42
URL: http://icssjournal.ir/article-1-208-en.html
1- Department of Psychiatry, Iran University of Medical Sciences, Mental Health Research Center, Tehran, Iran.
Abstract:   (5673 Views)
Objective: Regarding the inadequate knowledge about the course and prognosis of bipolar disorders and the lack of a longitudinal assessment of the course of this disorder in  Iran , this preliminary study was carried out on patients with first-episode mania. 
Method: In a longitudinal prospective study, 23 patients with first-episode mania who were admitted to  Iran medical and educational psychiatric center with a diagnosis of bipolar I disorder (BID) were evaluated. First, DSM-IV-TR diagnostic criteria, Hamilton Depression Rating Scale (HDRS), Young Mania Rating Scale (YMRS), and Yale-Brown Obsessive Compulsive Scale (YBOCS) were used. The three latter questionnaires were used every two to four months, and a diagnostic reassessment was carried out every six months. Patients were followed for 8 to 24 months (17±5.3). The history of psychiatric disorders in the patients' first degree relatives was obtained by interview and history taking. 
Results: The diagnosis of only one of the patients (4.3%) changed to schizophrenia. The other patients included 11 men and 11 women with the mean age of 28.4±10.4. Most patients were single and held a pre-high school degree. 31.8% had a history of depressive disorder. Substance abuse (except for nicotine) was present in only two patients. 9.1% had a comorbidity of anxiety disorders. 22.7% had relatives with BID and 13.6% had relatives with major depressive disorder. 40.9% of patients underwent a recurrence of mood episode. Two thirds of the recurrences took place in the first year and one third took place in the second year. 13.6% and 40.9% of patients experienced recurrence in the first six months and the first year (after improvement of first-episode mania) respectively. No mixed episodes or rapid cycling happened. Chi square test showed a significant statistical difference of a history of mood episodes before the first phase of mania, between patients with mania recurrence (71.4%) and patients without this recurrence (20.0%). 
Conclusion: The recurrence rate is significant in the early course of BID, and regarding the higher rate of recurrence in patients with history of depressive episodes, a serious prophylactic intervention, especially in this group of patients, is recommended.
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Type of Study: Research | Subject: Special
Received: 2006/05/15 | Accepted: 2006/07/23 | Published: 2006/09/23

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