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Volume 12, Issue 1 (Spring 2010)
Advances in Cognitive Sciences 2010, 12(1): 43-51 |
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Piri M, Nasehi M, Shahin M, Zarrindast M R. Effects of WIN55,212-2 in the Dorsal Hippocampus on Scopolamine State-Dependent Memory. Advances in Cognitive Sciences 2010; 12 (1) :43-51
URL: http://icssjournal.ir/article-1-80-en.html
URL: http://icssjournal.ir/article-1-80-en.html
1- Islamic Azad University, Ardabil Branch, Ardabil, Iran.
2- Islamic Azad University, Garmsar Branch, Garmsar, Iran.
3- Young Researchers Club, Islamic Azad University, Shahr-e-rey branch, Rey, Iran.
4- Tehran University of Medical Science, Tehran, Iran.
2- Islamic Azad University, Garmsar Branch, Garmsar, Iran.
3- Young Researchers Club, Islamic Azad University, Shahr-e-rey branch, Rey, Iran.
4- Tehran University of Medical Science, Tehran, Iran.
Abstract: (3132 Views)
Objective: To assess the effects of the cannabinoid receptor agonist, WIN55, 212-2 on scopolamine induced state-dependent memory.
Method: The step-down passive avoidance paradigm was used in the present study, which is an accepted model to examine long-term memory in mice.
Results: Post-training intra-CA1 administration of scopolamine (2 and 4 µg/mouse) decreased the memory retrieval. Pre-test scopolamine administration restored the retrieval to the control level in the test day. This phenomenon is known as scopolamine state-dependent memory. Administration of WIN55, 212-2 (1 µg/mouse, intra-CA1) 5 min before test by itself decreased the memory retrieval. On the other hand, the animals in which memory retrieval was impaired due to scopolamine (2 µg/mouse) post-training administration, pre-test administration of WIN55, 212-2 (1 µg/mouse, intra-CA1) 24 hr after training on the day of the test restored memory. Moreover, pre-test co-administration of non-effective dose of scopolamine with ineffective dose of WIN55, 212-2 increased the restoration of memory by scopolamine.
Conclusion: These results suggest that cannabinoid receptors of the dorsal hippocampal CA1 regions may play an important role in scopolamine-induced amnesia and scopolamine state-dependent memory.
Method: The step-down passive avoidance paradigm was used in the present study, which is an accepted model to examine long-term memory in mice.
Results: Post-training intra-CA1 administration of scopolamine (2 and 4 µg/mouse) decreased the memory retrieval. Pre-test scopolamine administration restored the retrieval to the control level in the test day. This phenomenon is known as scopolamine state-dependent memory. Administration of WIN55, 212-2 (1 µg/mouse, intra-CA1) 5 min before test by itself decreased the memory retrieval. On the other hand, the animals in which memory retrieval was impaired due to scopolamine (2 µg/mouse) post-training administration, pre-test administration of WIN55, 212-2 (1 µg/mouse, intra-CA1) 24 hr after training on the day of the test restored memory. Moreover, pre-test co-administration of non-effective dose of scopolamine with ineffective dose of WIN55, 212-2 increased the restoration of memory by scopolamine.
Conclusion: These results suggest that cannabinoid receptors of the dorsal hippocampal CA1 regions may play an important role in scopolamine-induced amnesia and scopolamine state-dependent memory.
Type of Study: Research |
Subject:
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Received: 2009/11/22 | Accepted: 2010/01/21 | Published: 2010/03/21
Received: 2009/11/22 | Accepted: 2010/01/21 | Published: 2010/03/21
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