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Volume 10, Issue 2 (Summer 2008)
Advances in Cognitive Sciences 2008, 10(2): 61-68 |
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Khodarehmi P, Oryan S, Razayof A, Zarindast M. Anxiety-Related Behaviors Induced by Histamine in Morphine Sensitized Rats. Advances in Cognitive Sciences 2008; 10 (2) :61-68
URL: http://icssjournal.ir/article-1-430-en.html
URL: http://icssjournal.ir/article-1-430-en.html
Abstract: (2903 Views)
Objective: In the present study, the effect of bilateral intrahippocampal administration of histamine on anxiety-related behavior in rats was investigated.
Method: The rats were first sensitized through 3 days of morphine administration and a 5 day drug-free period. The animals were then examined in a plus shaped maze.
Results: Intra-VHC bilateral administration of histamine decreased %OAT (Open Arm Times) and %OAE(Open Arm Entries) but not locomotor activity, thus showing an anxiogenic response. However, the administration of histamine to morphine-sensitized rats increased OAT and OAE in comparison with saline administered groups, which is indicative of a decrease in anxiety in the sensitized animals.
Conclusion: Bilateral administration of histamine in ventral hippocampus induces an anxiogenic effect, which decreases in morphine sensitized rats Naloxane antagonizes the effects of morphine on anxiety.
Method: The rats were first sensitized through 3 days of morphine administration and a 5 day drug-free period. The animals were then examined in a plus shaped maze.
Results: Intra-VHC bilateral administration of histamine decreased %OAT (Open Arm Times) and %OAE(Open Arm Entries) but not locomotor activity, thus showing an anxiogenic response. However, the administration of histamine to morphine-sensitized rats increased OAT and OAE in comparison with saline administered groups, which is indicative of a decrease in anxiety in the sensitized animals.
Conclusion: Bilateral administration of histamine in ventral hippocampus induces an anxiogenic effect, which decreases in morphine sensitized rats Naloxane antagonizes the effects of morphine on anxiety.
Type of Study: Research |
Subject:
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Received: 2008/02/13 | Accepted: 2008/04/20 | Published: 2008/06/21
Received: 2008/02/13 | Accepted: 2008/04/20 | Published: 2008/06/21
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