TY - JOUR T1 - Dopamine D1 and NMDA Receptors Interaction in the Dorsal Hippocampus of Rats in the Elevated Plus Maze Test of Anxiety TT - برهمکنش گیرنده های D1 دوپامینی و NMDA در هیپوکامپ پشتی موش صحرایی در آزمون اضطراب ماز بعلاوه ای شکل مرتفع JF - icss JO - icss VL - 13 IS - 1 UR - http://icssjournal.ir/article-1-321-en.html Y1 - 2011 SP - 81 EP - 92 KW - Dopamine D1 Receptor KW - NMDA Receptor KW - Anxiety KW - Elevated Plus Maze KW - Rats N2 - Objective: In this study the effects of dopaminergic D1 receptor of dorsal hippocampus on anxiety-like behavior induced by stimulation or inhibition of NMDA receptors were investigated in male Wistar rats. Method: The elevated plus maze was used in the present study, which is an accepted model to examine anxiety-like behaviors in mice and rats. Results: The results indicate that intra-CA1injection of MK801 (2 μg/rat) induce anxiolytic effects. Intra-CA1 injection of SCH23390 (0.25, 0.5 and 1 μg/rat) by itself has no effect on anxiety-like behaviors, but administration of same doses of SCH23390 before MK801 (1 μg/rat, intra-CA1) potentiate anxiolytic effects of MK801. On the other hand, intra-CA1 injection of NMDA (0.3 and 0.6 μg/rat) or SKF 38393 (3 and 6 μg/rat) by itself induces anxiogenic effects. Injection of different doses of SKF38393 before NMDA potentiated anxiogenic effects of NMDA. Conclusion: These results show that both NMDA receptor and dopaminergic D1 receptor not only play a part in the modulation of anxiety in the dorsal hippocampus of rats but also have demonstrated a complex interaction as well. M3 ER -