%0 Journal Article %A Shaabani, Amir %A Eftekhar, Mehrdad %A Danesh Amouz, Badri %A Khaniha, Hamidreza %A Hakim Shoushtari, Mitra %A Ghaleh Band, Mirfarhad %A Panaghi, Leili %T Degree of Recurrence of Type I Bipolar Disorder: A 17 Month Follow-Up of Patients With First-Episode Mania %J Advances in Cognitive Sciences %V 8 %N 3 %U http://icssjournal.ir/article-1-208-en.html %R %D 2006 %K Bipolar Disorder, Mania, Major Depression, Outcome, Recurrence, Comorbidity, %X Objective: Regarding the inadequate knowledge about the course and prognosis of bipolar disorders and the lack of a longitudinal assessment of the course of this disorder in Iran , this preliminary study was carried out on patients with first-episode mania. Method: In a longitudinal prospective study, 23 patients with first-episode mania who were admitted to Iran medical and educational psychiatric center with a diagnosis of bipolar I disorder (BID) were evaluated. First, DSM-IV-TR diagnostic criteria, Hamilton Depression Rating Scale (HDRS), Young Mania Rating Scale (YMRS), and Yale-Brown Obsessive Compulsive Scale (YBOCS) were used. The three latter questionnaires were used every two to four months, and a diagnostic reassessment was carried out every six months. Patients were followed for 8 to 24 months (17±5.3). The history of psychiatric disorders in the patients' first degree relatives was obtained by interview and history taking. Results: The diagnosis of only one of the patients (4.3%) changed to schizophrenia. The other patients included 11 men and 11 women with the mean age of 28.4±10.4. Most patients were single and held a pre-high school degree. 31.8% had a history of depressive disorder. Substance abuse (except for nicotine) was present in only two patients. 9.1% had a comorbidity of anxiety disorders. 22.7% had relatives with BID and 13.6% had relatives with major depressive disorder. 40.9% of patients underwent a recurrence of mood episode. Two thirds of the recurrences took place in the first year and one third took place in the second year. 13.6% and 40.9% of patients experienced recurrence in the first six months and the first year (after improvement of first-episode mania) respectively. No mixed episodes or rapid cycling happened. Chi square test showed a significant statistical difference of a history of mood episodes before the first phase of mania, between patients with mania recurrence (71.4%) and patients without this recurrence (20.0%). Conclusion: The recurrence rate is significant in the early course of BID, and regarding the higher rate of recurrence in patients with history of depressive episodes, a serious prophylactic intervention, especially in this group of patients, is recommended. %> http://icssjournal.ir/article-1-208-en.pdf %P 33-42 %& 33 %! %9 Research %L A-10-2-187 %+ Department of Psychiatry, Iran University of Medical Sciences, Mental Health Research Center, Tehran, Iran. %G eng %@ 1561-4174 %[ 2006