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Volume 4, Issue 3 (Autumn 2002)
Advances in Cognitive Sciences 2002, 4(3): 1-11 |
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Zarindast M R, Rezayof A. The Effects of Morphine Sensitization on Morphine-State-Dependent Learning. Advances in Cognitive Sciences 2002; 4 (3) :1-11
URL: http://icssjournal.ir/article-1-570-en.html
URL: http://icssjournal.ir/article-1-570-en.html
Abstract: (2991 Views)
In the present study, the effects of morphine sensitization on morphine-induced impairment of memory formation and the state-dependent retrieval of a passive avoidance task learned under morphine influence have been investigated in mice. Pre-training administration of morphine (0.5, 2.5 and 5mg/kg) dose dependently suppressed the learning of one-trial passive avoidance task. Pre-test administration of morphine (0.5, 2.5 and 5 mg/kg) induced state-dependent retrieval of the memory acquired under pretrainign morphine influence. The inhibitory effect of morphine (5 mg/kg) on memory formation was significantly antagonized by pretreatment administation of naloxone (0.025, 0.5 and 1 mg/kg) before .the pre-training morphine. The pre-test administration of naloxone dose dependently inhibited the restoration induced by morphine (5 mg/kg). Amnesia induced by pre-training morphine significantly was inhibited in morphine-sensitized mice, which had previously received once daily injections of morphine (20 and 30 mg/kg, s.c.) for 3 days. Morphine sensitization did not affect on morphine state-dependent memory of passive avoidance. The inhibition of morphine-induced amnesia in morphine-sensitized mice was suppressed by one daily injections of naloxone (0.5, 1 and 2 mg/kg) 30 min prior to s.c. injections of morphine (20 mg/kg/day × 3 days). These results suggest that morphine sensitization affect the impairment of memory formation, but not the facilitation of retrieval induced by morphine.
Type of Study: Research |
Subject:
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Received: 2002/06/1 | Accepted: 2002/07/23 | Published: 2002/09/23
Received: 2002/06/1 | Accepted: 2002/07/23 | Published: 2002/09/23
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