Volume 8, Issue 1 (Spring 2006)
Advances in Cognitive Sciences 2006, 8(1): 9-16 |
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1- Department of Science and Research, Islamic Azad University, Tehran, Iran.
Abstract: (3384 Views)
Objective: In the present study interaction of glucose and ATP sensitive potassium channels on the consolidation of morphine induced place preference in male mice has been investigated.
Methods: Conditioned place preference method was used to assess morphine reward and effects of glucose ,glibenclamide and diazoxide on it.
Results: Intraperitoneal administration of different doses of morphine sulphate (0.5-7.5 mg/kg IP) produced a dose-dependent conditioned place preference (cpp). However, the isolated administration of different doses of glibenclamide (3,6 AND12mg/kg IP), diazoxide (15, 30 and 60mg/kg IP) and glucose (100, 200, 500, 2000 mg/kg) did not produce such an effect. The injection of glucose (2000 mg/kg IP) and glibenclamide (6 mg/kg IP) produced significant morphine (0.5 mg/kg IP) induced cpp. Also, the response of glibenclamide (6mg/kg IP) was attenuated by diazoxide (60 mg /kg IP). However, this dose of diazoxide alone had no effect on morphine (0.5 mg/kg IP) induced cpp .Injection of different doses of diazoxide (15, 30 and 60mg/kg IP), glibenclamide (3, 6 and 12mg/kg IP) and morphine (0.5-7.5 mg/kg) did not effect blood glucose level.
Conclusion: It is concluded that glucose may be involved in morphine induced conditioned place preference through KATP channels.
Methods: Conditioned place preference method was used to assess morphine reward and effects of glucose ,glibenclamide and diazoxide on it.
Results: Intraperitoneal administration of different doses of morphine sulphate (0.5-7.5 mg/kg IP) produced a dose-dependent conditioned place preference (cpp). However, the isolated administration of different doses of glibenclamide (3,6 AND12mg/kg IP), diazoxide (15, 30 and 60mg/kg IP) and glucose (100, 200, 500, 2000 mg/kg) did not produce such an effect. The injection of glucose (2000 mg/kg IP) and glibenclamide (6 mg/kg IP) produced significant morphine (0.5 mg/kg IP) induced cpp. Also, the response of glibenclamide (6mg/kg IP) was attenuated by diazoxide (60 mg /kg IP). However, this dose of diazoxide alone had no effect on morphine (0.5 mg/kg IP) induced cpp .Injection of different doses of diazoxide (15, 30 and 60mg/kg IP), glibenclamide (3, 6 and 12mg/kg IP) and morphine (0.5-7.5 mg/kg) did not effect blood glucose level.
Conclusion: It is concluded that glucose may be involved in morphine induced conditioned place preference through KATP channels.
Type of Study: Research |
Subject:
Special
Received: 2005/09/24 | Accepted: 2005/12/19 | Published: 2006/03/21
Received: 2005/09/24 | Accepted: 2005/12/19 | Published: 2006/03/21
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