Volume 8, Issue 3 (Autumn 2006)                   Advances in Cognitive Sciences 2006, 8(3): 1-10 | Back to browse issues page

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Malek mohammadi N, Khalilzadeh A, Fazli Tabaei S, Zarindast M. Influence of Morphine- or Apomorphine-Induced Sensitization on Histamine State-Dependent . Advances in Cognitive Sciences. 2006; 8 (3) :1-10
URL: http://icssjournal.ir/article-1-202-en.html
1- Department of Pharmacology, Faculty of Medicine, Tehran University of Medical Sciences, National Center for Addiction Studies, Tehran, Iran.
Abstract:   (943 Views)
Objective: To survey the interaction of morphine and histamine and the involvement of dopaminergic system on histamine state-dependent learning in step-down passive avoidance test. 
Method: First, with the administration of 3 different doses of morphine for three days and a subsequent five days of no drug treatment, mice were sensitized to morphine. Then, the necessary memory tests were carried out and the effect of histamine on the memories of morphine-sensitized mice and non-sensitized mice was compared. Step-down passive avoidance test was used to assess memory. 
Results: Sensitization with morphine and apomorphine prevented histamine-induced memory impairment and memory was retrieved. However, the co-administration of apomorphine and sulpride as a D2 receptor antagonist decreased the effect of memory retrieval; but the administration of SCH 23390 as a dopamine 1 receptor antagonist had no such effect. Also, the co-administration of naloxone, SCH 23390, and sulpride, plus morphine significantly decreased the effect of memory retrieval. 
Conclusion: Apomorphine activates the histaminergic neural system through stimulation of D2 receptors and the improvement of memory in morphine sensitized mice through the stimulation of opioid and D1 and D2 receptors.
Full-Text [PDF 234 kb]   (194 Downloads)    
Type of Study: Research | Subject: Special
Received: 2006/05/23 | Accepted: 2006/07/23 | Published: 2006/09/23

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